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Three Problems
One Clear Solution

PuraSinus® is the 3 in l hydrogel solution providing unrivalled value and results. The fast-acting hydrogel aids in wound healing, adhesion prevention, and bleeding control.

Comprised of synthetic self-assembling peptides, the unique mode of action and physical properties offer the ENT surgeon a single solution to three common complications of sinus surgery. PuraSinus® enables precise delivery of the ready to use, transparent hydrogel from the prefilled syringe without obscuring the surgical field.

The PuraSinus® nanofiber peptides self­-assemble on contact with physiological fluid to form a synthetic matrix that mimics ECM. The matrix serves as a scaffold, forming a mechanical barrier to control minimal bleeding, and maintains moisture on exposed mucosa, aiding the natural healing process and preventing the formation of post­operative adhesions.

PuraSinus® sets a new standard for product consolidation without compromising clinical performance and patient outcomes. PuraSinus® is available in 2 different kit volumes to minimize waste and provide optimal value per patient.

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PuraSinus® Technology

The matrix is formed from synthetic peptides which are composed of three naturally occurring amino acids in a sequence which is repeated 4 times. The peptides self-assemble to form a 3 dimensional matrix upon a change in pH caused by exposure to an ionic solution such as blood, peritoneal fluid or other bodily secretions.

Product Advantages

PuraSinus® mimics Extracellular Matrix

The peptides in PuraSinus® are synthetized in a specific sequence which provide the molecule with shape memory to enable them to self assemble into a scaffold which mimics human extracellular matrix (ECM).

Based on results of scanning electron microscopy, the structure of PuraSinus® self-assembling peptide hydrogel is understood to be a network of fibres with a diameter of around 10–20 nm and pores with a diameter of about 50–200 nm that resembles the mesh structure of natural collagen.

PuraStat® does not swell

In internal testing PuraSinus® does not swell after implantation or during the resorption process. This is because unlike other hydrogels which are designed to absorb water as part of their breakdown cycle, PuraSinus is broken down by enzymatic action.

As PuraSinus® doesn’t swell it will not cause compression of underlying tissues of structures, or prevent that natural physiologic dilatation of vessels.

PuraSinus® = No Assembly or Preparation

PuraSinus® is delivered in a prefilled syringe, just connect the applicator using the luer and the product is ready to use.

Revolutionary Bleeding Control

The trigger for the peptides in PuraSinus® to begin self assembly is a change in ionic charge. PuraSinus® is acidic so when in contact with neutral liquids the reduction in ionic charge causes the rapid self assembly of β-sheets. The β-sheets then transition to form a complex network of fibres with a diameter of around 10–20 nm and pores with a diameter of about 50–200nm that resembles the mesh structure of natural collagen. The formation of this complex fibre network rapidly seals the bleeding point leading to hemostasis.

PuraSinus® is 100% Synthetic

The peptides are made from chemically synthesized amino acids to guarantee the final product is contamination free. The amino acids are bonded together in a specific sequence at a 2.5% concentration in aqueous solution to make PuraSinus®.

PuraSinus® is Resorbed in 30 Days

PuraSinus® is broken down by the actions of enzymes which break down the peptide scaffold into the constituent amino acids over approximately 30 days. The amino acids are metabolised by the body or excreted if they are surplus to requirements.

PuraSinus® is Suturable & Clipable

Because PuraSinus® forms a liquid hydrogel, it is largely composed of water and remains completely flexible once applied. Because it does not harden or cure it remains soft and can easily be sutured through should the need arise.

This also means that you can place surgical or endoscopic clips directly through a layer of PuraSinus®, this is very helpful if using PuraSinus® to clearly identify bleeding points when bleeding is more profuse or persistent.

PuraSinus® is Transparent

This image demonstrates the transparency of PuraSinus®. Once applied clear visualisation of the underlying tissue is maintained.

PuraSinus® Will Not Migrate

PuraSinus® is naturally viscous, this means, with proper application, it will not run or fall away from the application site. When in contact with blood the change in pH causes the self assembly of PuraSinus® to occur rapidly at the interface between it and the bleeding point, gaining further integral strength as the reaction occurs. Any PuraSinus® not incorporated in the final clot will separate and may be left in situ.



  • Adhesion Prevention
    • PuraSinus separates and prevents adhesions between mucosal surfaces.
  • Controls Bleeding
    • PuraSinus helps to control minimal bleeding following surgery or nasal trauma.
  • Aids Wound Healing
    • PuraSinus acts as an adjunct to aid in the natural healing process.

Products from 3-D Matrix


Whereas PuraStat® is a slightly viscous solution, it fits requirements for a haemostat in endoscopy and in laporoscopy, including robotic/ robot assisted procedures.