Advanced Peptide Technology

The matrix is formed from synthetic peptides which are composed of three naturally occurring amino acids in a sequence which is repeated 4 times (Arginine - Alanine - Aspartic Acid - Alanine). The peptides self assemble to form a matrix upon a change in pH caused by exposure to an ions such as Na+ (sodium) or K+ (potassium). Each amino acid, when assembled into a peptide, will take part in creating a specific three dimensional shape. The amino acids are synthesized in a very specific order, and in doing so a very specific shape-forming capability will be programmed into the peptide.

RADA-16 molecule
Mammalian ECM
a

Mammalian ECM1

X15,0001Mm
Mammalian ECM
b

PuraStat Scaffold1

X15,0001Mm

The peptides in PuraStat® are synthetized in a specific sequence which provide the molecule with shape memory to enable them to self assemble into a scaffold which mimics human extra cellular matrix (ECM). Based on results of scanning electron microscopy, the structure of PuraStat® self-assembling peptide hydrogel is understood to be a network of fibres with a diameter of around 10–20 nm and pores with a diameter of about 50–200 nm that resembles the mesh structure of natural collagen.

1
Dhwani J. ,Rajesh V. A Review on Extracellular Matrix Mimicking Strategies for an Artificial Stem Cell Niche. Polymer Reviews. 2015, 55:4, 561-595, DOI:10.1080/15583724.2015.1040552
Global, Agile and Local

Global, Agile and Local

Since the inceptions of 3-D Matrix as a spinoff from MIT in 2004, 3-D Matrix has grown to become leading global peptide solutions company headquartered in Tokyo, Japan. With offices serving the Americas, Europe and Asia our employees together with our partners and distributor serve research scientists, healthcare providers and patients around the globe. Learn More »

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Products from 3-D Matrix

Applicators

Whereas PuraStat® is a slightly viscous solution, it fits requirements for a haemostat in endoscopy and in laporoscopy, including robotic/ robot assisted procedures.

PuraStat®

PuraStat is a synthetic haemostatic material in the form of a prefilled syringe, filled with a clear, aqueous peptide solution.Contact between the product and liquids such as blood leads to the formation of fibres in the aqueous solution, yielding a peptide hydrogel. The hydrogel quickly coats the point of bleeding and, by physically closing the superficial part of the broken blood vessel, causes blood coagulation in the deeper part of the vascular wall, resulting in haemostasis.